Determinants of organotropic metastasis

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August undefined, 2024

WebDeterminants of Organotropic Metastasis Heath A. Smith and Yibin Kang Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544; email: … Webthe biological underpinnings of organotropic metastasis while computational approaches have developed tools attempting to predict the sites of metastases. Previous research has described the patterns of bone, liver, and lung tropisms. Bone tropisms arise primarily from breast and prostate cancers [13]. In prostate cancers, three

Organotropic metastasis: role of tumor exosomes

WebAs cancer progresses, rogue tumor cells escape the primary organ via the lymphatic system, as well as via hematogenous and transcoelomic tissues, to establish metastatic outgrowths in new organs [1,2]. The late 19th … WebSep 11, 2024 · Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological ... highlights genoa cosenza

Pre-metastatic niches: organ-specific homes for …

WebFeb 1, 2024 · Evidences of such intricate metabolic patterns of organotropic metastasis have been extensively summarised in specific reviews [18,[131][132] [133] [134]. … WebApr 29, 2024 · Metastatic cells interact with osteoblasts and osteoclasts in the bone microenvironment to promote the release of growth factors in the bone matrix and thus … WebNov 24, 2024 · The model improves on previous work in two fundamental ways. The model increases the scope and performance comparison to previous work modeling either a … highlights genoa palermo

Modeling the mechanisms of metastasis MIT News

Biophysical determinants of cancer organotropism

WebDec 7, 2024 · Determinants of cancer progression have been examined from the framework of tumor genetics and metabolism in concert with physicochemical cues from the stromal cells within the organ microenvironment [81]. ... Tumour exosome integrins determine organotropic metastasis. Nature (2015) K.J. Pienta The cancer diaspora: … WebDec 25, 2015 · Many studies focus largely on identifying cell-intrinsic determinants of such organotropic metastasis, including genes and … small pointing trowelWebThe spread of cancer from a primary tumor to distant organ sites is the most devastating aspect of malignancy. Dissemination to specific organs depends upon blood flow … highlights genoa lazio

"WebOne of the first studies to demonstrate the systemic organotropic effects of tumor-secreted factors revealed that preconditioned media from B16 melanoma cells could redirect lung cancer cells to metastatic sites typical of melanoma, such as the spleen, intestine, … " - Determinants of organotropic metastasis

Determinants of organotropic metastasis

Webcell-intrinsic determinants of such or-ganotropic metastasis, including genes and chemokine receptors expressed on cancer cells [2]. The adhesion and extracellular matrixc molecules, such as integrins, tenascin and periostin, have been also shown to promote coloniza-tion of metastatic cancer cells [3]. In 2005, Dr Lyden and colleagues pro- WebOct 7, 2024 · For organotropic metastasis, Paget proposed the ‘seed and soil’ theory, which states that metastases develop only when the ‘seed’ (tumor cells) and the ‘soil’ (target organs) are compatible (Paget, 1989; Fidler et al., 2002). It is only recently that studies have begun to reveal some of the identities of the ‘seed and soil ...

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WebNov 24, 2024 · Conclusions: We have demonstrated that site specific metastatic progression is predictable using transcriptomic profiling data from primary tumors and that the overrepresented biological processes in tumors metastasizing to congruent distant loci are highly overlapping. These results indicate site-specific progression was … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆

WebMar 13, 2024 · Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites of organotropic metastasis, preparing these distant … WebFeb 16, 2024 · For example, miR-122 promotes breast cancer metastasis to the brain and lungs by reprogramming glucose metabolism in the PMN. 29 Expression of the miR-23b/27b/24 cluster promotes lung metastasis ...

Webcell-intrinsic determinants of such or-ganotropic metastasis, including genes and chemokine receptors expressed on cancer cells [2]. The adhesion and extracellular … WebDeterminants of organotropic metastasis. Heath A. Smith, Yibin Kang. Molecular Biology; Princeton University. Research output: Contribution to journal › Article › peer-review. 12 …

WebMay 25, 2024 · e13502 Background: The clinical manifestation of metastatic colorectal cancer (mCRC) varies from patient to patient, with the underlying genetic alterations and expression profiles deceptive. We aim to investigate the phylogenetic relationships of the multi-organ mCRC and the possible biomarkers of disease progression. Methods: Whole … highlights gennadiy golovkinWebMar 13, 2024 · The PMN immune landscape and inflammation. Modulation of immune cell function at pre-metastatic organ sites (e.g., lung, liver, bone, and LNs) is a critical step in PMN formation. These cells interact with resident stromal cells, such as fibroblasts and endothelial cells, as well as each other, to reprogram the distal microenvironment. highlights genoa ternanaWebMetastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induce … highlights genoa spalWeb肿瘤来源的细胞外囊泡 (ev) 在远处器官微环境的选择性调节中作为关键介质发挥作用，以产生促进器官转移的转移前生态位。鉴定 ev 的器官特异性分子决定因素可以开发潜在的抗转移治疗靶点。在当前的研究中，发现大肿瘤小体 (lo)，即非典型的大型癌症衍生 ev，通过设计破骨细胞转移前生态位并 ... highlights georgia vs alabamaWebNov 5, 2024 · The technology, which facilitates simultaneous 3D, multi-cell type cultures, has been applied to investigations of vascular barrier function, amyotrophic lateral … highlights genuaWebImmune determinants of the pre-metastatic niche. Review Overview abstract . Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites of organotropic metastasis, preparing these distant microenvironments for disseminated tumor cell arrival. While initial studies of the PMN focused on extracellular matrix ... highlights georgia alabamaWebarchitecture to predict organotropic metastases ... determinants of tissue speci c progression. Methods: We used statistical machine learning for transcript feature selection to optimize classi ... small pokemon card cases