WebFrom the oncology field is known that Rbm38 has a role in the stabilization of the cell cycle inhibitor p21. 8, 25 Indeed we found silencing of Rbm38 to significantly inhibit p21 levels which was ...
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WebMar 21, 2024 · RBM38 (RNA Binding Motif Protein 38) is a Protein Coding gene. Diseases associated with RBM38 include Lung Cancer and Erythema Infectiosum . Gene Ontology … WebMar 14, 2024 · Rbm38, an RNA-binding protein, has been implicated in cell-cycle regulation and differentiation ().Consistent with its cellular activities, Rbm38 is necessary for normal hematopoiesis and loss of Rbm38 leads to accelerated aging and spontaneous tumors in mice ().The diverse biological functions of Rbm38 are probably due to its role as an RNA …
WebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to … WebThe levels of RBM38 and HIF1α transcripts were normalized to that of the GAPDH transcript. The relative fold change ... Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription …
WebDownload scientific diagram RBM38 directly binds to HIF1α 5′ and 3′ UTRs. (A) Whole cell lysates from H1299 cells were collected and immunoprecipitated with anti-RBM38 … WebThe RNA-binding protein Rbm38, also called RNPC1, is a 7, 8). Rbm38 is found to regulate expression of genes necessary for several cellular processes, including cell growth and differenti-ation. For example, Rbm38 is found to regulate Mdm2, p21, p73, and Pten mRNA stability through binding to the AU/U-rich elements in their 3UTRs ( 8–11).
WebBioGRID Interaction 2470505 Between RBM38 And HIF1A. Toggle navigation. Bio GRID 4.4
WebJan 6, 2015 · PDF Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, ... Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 … to build a home step up danceWebAlternative Name: HIF1; HIF-1A; HIF1A; HIF-1-alpha; HIF1-alpha; BHLHE78; MOP1; PASD8 Reactivity: Human (QC Testing) Isotype: Mouse IgG1, κ Immunogen: Human HIF-1α aa. 610-727 Application: Western blot (Routinely Tested), Immunofluorescence (Tested During Development) ... penny barber phone numberWebApr 1, 2024 · Interestingly, RBM38 is unique in that it can either suppress or enhance p53 mRNA translation via altered interaction with eIF4E potentially mediated by serine-195 (S195) in RBM38. Thus, multiple RBM38/eIF4E knock-in (KI) cell lines were generated to investigate the significance of eIF4E-RBM38 interaction in controlling p53 activity. penny bank court rugeleyWebMar 21, 2024 · Background: Current studies have revealed that RNA-binding protein RBM38 is closely related to tumor development, while its role in malignant melanoma remains unclear. Therefore, this research aimed to investigate the function of RBM38 in melanoma and the prognosis of the disease. Methods: Functional experiments (CCK-8 assay, cell … to build a kingdom of love课文翻译WebThe RNA Binding Protein RBM38 (RNPC1) Regulates Splicing during Late Erythroid Differentiation Laurie A. Heinicke1¤a, Behnam Nabet2¤b, Shihao Shen3,4, Peng Jiang3¤c, Sebastiaan van Zalen1, Benjamin Cieply1, J. Eric Russell1,5, Yi Xing3,4, Russ P. Carstens2,6* 1 Department of Medicine (Hematology-Oncology Division), Perelman School of Medicine, … penny banner matchesWebNov 23, 2024 · Objective The study is to research how miR-34-SIRT1 is regulated during hypoxia in lung cancer cells. Results Analysis of publicly available datasets from patients … to build a home suitsWebApr 17, 2024 · Increased expression of the HIF1 targets Adm, Vegf, Glut1, Pdk1, and Egl-9 family hypoxia-inducible factor 1 (Egln1) in rod ΔVhl and rod ΔVhl;Hif2a mice verified that HIF1 was transcriptionally ... penny bar 6959 s loomis rd waterford wi